Directora del Departamento de Investigación de la VIDCA y Académico
Instituto de Farmacología y Morfofisiología
Grado Académico: Bioquímico, Universidad Austral de Chile, 2000. Doctor en Ciencias, Universidad Austral de Chile, 2006.
E-mail: mahidalgo@uach.cl
Teléfono: 632221065
Líneas investigación: Inmunidad innata y receptores de ácidos grasos. Estudio de la activación de receptores de ácidos grasos de cadena larga en inmunidad innata en bovinos.
Publicaciones
María Angélica Hidalgo
- 2012 Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F- actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. Vet Immunol Immunopathol 145, 540-545.
- 2012 Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l- selectin shedding in bovine neutrophils. Res Vet Sci. 92, 103-110.
- 2013 Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils. Veterinary Immunology and Immunopathology. 151, 275-284.
- 2013 Propionate induces the release of granules from bovine neutrophils. The Journal of Dairy Science. 96(4):2507-20
- 2014 Decreased cyclooxygenase-2 gene expression and lactoferrin release in blood neutrophils of heifers during the calving period. Vet Immunol Immunop. 160, 139-44.
- 2014 Delphinidin activates NFAT and induces IL-2 production through SOCE in T cells. Cell Biochem Biophys. 68, 497-509.
- 2014 Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers. J Vet Sci 15, 217-24
- 2015 Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils. PLoS One. 10(3):e0119715. doi: 10.1371/journal.pone.0119715. eCollection
- 2015 Eimeria bovis-triggered neutrophil extracellular trap formation is CD11b-, ERK 1/2-, p38 MAP kinase- and SOCE-dependent. Vet Res. 2015 Mar 5;46:23. doi: 10.1186/s13567-015-0155-6.
- 2015 fMLP- Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils. J Immunol. Res., 2015, Article ID 120348, 14 pages. http://dx.doi.org/10.1155/2015/120348
- 2015 Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1. Innate Immun. 2015 Apr;21(3):289-304
- 2016 Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor.Vet Immunol Immunopathol. 2016 Aug;176:18-27.
- 2016 Differential free fatty acid receptor-1 (FFAR1/GPR40) signalling is associated with gene expression or gelatinase granule release in bovine neutrophils. Innate Immun. 2016 Aug;22(6):479-89.
- 2016 Differential intracellular calcium influx, nitric oxide production, ICAM-1 and IL8 expression in primary bovine endothelial cells exposed to nonesterified fatty acids. BMC Vet Res 2016 Feb 25;12(1):38.
- 2016 Far beyond phagocytosis: phagocyte-derived extracellular traps act efficiently against protozoan parasites in vitro and in vivo. Mediators of Inflammation 22(6):479-89
- 2016 Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells. J Cell Biochem. 2016 Nov 10. doi: 10.1002/jcb.25790
- 2017 Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na+/H+ exchanger 1. Vet Immunol Immunopathol. 2017 Sep; 191:68-73. doi: 10.1016/j.vetimm.2017.08.007. Epub 2017 Aug 26
- 2017 d(-) Lactic Acid-Induced Adhesion of Bovine Neutrophils onto Endothelial Cells Is Dependent on Neutrophils Extracellular Traps Formation and CD11b Expression. Front Immunol. 2017 Aug 15;8:975. doi: 10.3389/fimmu.2017.00975. eCollection
- 2017 Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40. Int J Mol Sci. 2017 Apr 5;18(4)
- 2017 Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells. J Cell Biochem. 2017 Jun;118(6):1330-1340. doi: 10.1002/jcb.25790. Epub 2017 Jan 10.
- 2018 Fatty and hydrocarboxylic acid receptors: The missing link of immune respone and metabolism in cattle. Vet Immunol Immunopathol. ;201:77-87. doi: 10.1016/j.vetimm.2018.05.009
- 2019 Docosahexaenoic acid and TUG-891 activate free fatty acid-4 receptor in bovine neutrophils. Vet Immunol Immunopathol. 209: 53-60
- 2019 Functional expression of the free fatty acids receptor-1 and -4 (FFA1/GPR40 and FFA4/GPR120) in bovine endometrial cells. Vet Res Commun. 2019 Aug;43(3):179-186
- 2019 Metabolic disturbances in synovial fluid are involved in the onset of synovitis in heifers with acute ruminal acidosis. Sci Rep. 9(1):5452
- 2019 Proinflammatory mediators and neutrophils are increased in synovial fluid from heifers with acute ruminal acidosis. BMC Vet Res. 15(1):225