Directora del Departamento de Investigación de la VIDCA y Académico
Instituto de Farmacología y Morfofisiología
Grado Académico: Bioquímico, Universidad Austral de Chile, 2000. Doctor en Ciencias, Universidad Austral de Chile, 2006.
E-mail: mahidalgo@uach.cl
Teléfono: 632221065
Líneas investigación: Inmunidad innata y receptores de ácidos grasos. Estudio de la activación de receptores de ácidos grasos de cadena larga en inmunidad innata en bovinos.
Publicaciones
2019 Proinflammatory mediators and neutrophils are increased in synovial fluid from heifers with acute ruminal acidosis. BMC Vet Res. 15(1):225
2019 Metabolic disturbances in synovial fluid are involved in the onset of synovitis in heifers with acute ruminal acidosis. Sci Rep. 9(1):5452
2019 Functional expression of the free fatty acids receptor-1 and -4 (FFA1/GPR40 and FFA4/GPR120) in bovine endometrial cells. Vet Res Commun. 2019 Aug;43(3):179-186
2019 Docosahexaenoic acid and TUG-891 activate free fatty acid-4 receptor in bovine neutrophils. Vet Immunol Immunopathol. 209: 53-60
2018 Fatty and hydrocarboxylic acid receptors: The missing link of immune respone and metabolism in cattle. Vet Immunol Immunopathol. ;201:77-87. doi: 10.1016/j.vetimm.2018.05.009
2017 Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells. J Cell Biochem. 2017 Jun;118(6):1330-1340. doi: 10.1002/jcb.25790. Epub 2017 Jan 10.
2017 Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40. Int J Mol Sci. 2017 Apr 5;18(4)
2017 d(-) Lactic Acid-Induced Adhesion of Bovine Neutrophils onto Endothelial Cells Is Dependent on Neutrophils Extracellular Traps Formation and CD11b Expression. Front Immunol. 2017 Aug 15;8:975. doi: 10.3389/fimmu.2017.00975. eCollection
2017 Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na+/H+ exchanger 1. Vet Immunol Immunopathol. 2017 Sep; 191:68-73. doi: 10.1016/j.vetimm.2017.08.007. Epub 2017 Aug 26
2016 Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells. J Cell Biochem. 2016 Nov 10. doi: 10.1002/jcb.25790
2016 Far beyond phagocytosis: phagocyte-derived extracellular traps act efficiently against protozoan parasites in vitro and in vivo. Mediators of Inflammation 22(6):479-89
2016 Differential intracellular calcium influx, nitric oxide production, ICAM-1 and IL8 expression in primary bovine endothelial cells exposed to nonesterified fatty acids. BMC Vet Res 2016 Feb 25;12(1):38.
2016 Differential free fatty acid receptor-1 (FFAR1/GPR40) signalling is associated with gene expression or gelatinase granule release in bovine neutrophils. Innate Immun. 2016 Aug;22(6):479-89.
2016 Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor.Vet Immunol Immunopathol. 2016 Aug;176:18-27.
2015 Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1. Innate Immun. 2015 Apr;21(3):289-304
2015 fMLP- Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils. J Immunol. Res., 2015, Article ID 120348, 14 pages. http://dx.doi.org/10.1155/2015/120348
2015 Eimeria bovis-triggered neutrophil extracellular trap formation is CD11b-, ERK 1/2-, p38 MAP kinase- and SOCE-dependent. Vet Res. 2015 Mar 5;46:23. doi: 10.1186/s13567-015-0155-6.
2015 Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils. PLoS One. 10(3):e0119715. doi: 10.1371/journal.pone.0119715. eCollection
2014 Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers. J Vet Sci 15, 217-24
2014 Delphinidin activates NFAT and induces IL-2 production through SOCE in T cells. Cell Biochem Biophys. 68, 497-509.
2014 Decreased cyclooxygenase-2 gene expression and lactoferrin release in blood neutrophils of heifers during the calving period. Vet Immunol Immunop. 160, 139-44.
2013 Propionate induces the release of granules from bovine neutrophils. The Journal of Dairy Science. 96(4):2507-20
2013 Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils. Veterinary Immunology and Immunopathology. 151, 275-284.
2012 Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l- selectin shedding in bovine neutrophils. Res Vet Sci. 92, 103-110.
2012 Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F- actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. Vet Immunol Immunopathol 145, 540-545.
Proyectos
